Outlook Error 0x80042108 Microsoft Outlook reports the following error when trying to send: 0x80042108 The Operation timed out waiting for a response from the sending (SMTP) server. If you continue to receive this message, contact your server administrator or Internet Service Provider (ISP)

This typically occurs when the machine you are on cannot connect to SMTPRA on port 25.

• Disable any anti virus software on the machine. Some anti virus software programs have additional security options which block connections on port 25
• Restart Outlook
• From a command prompt you can verify outbound connections on port 25 by using the telnet command (eg. telnet mail.rockliffe.com 25) and waiting to see if you get a response